GABA Receptor

Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor

GABA Receptor

Related Products

GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

GABA Receptor Related Products (765)
Antibodies (14)
Related Compound Screening Libraries (1)

By Effects:	Agonists (189)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-129927

Thiomuscimol	Agonist	99.90%
Thiomuscimol is a GABAA receptor agonist (IC₅₀=19 nM). It has been used as a photoaffinity label for the purification and identification of GABA binding sites within the GABAA receptor complex.

HY-101411R

4-Acetamidobutanoic acid (Standard)	Agonist
Josamycin propionate (Standard) is the analytical standard of Josamycin propionate. This product is intended for research and analytical applications. Josamycin propionate is classified as a macrolide antibiotic.

HY-117979

Alphadolone	Agonist	98.71%
Alphadolone is a GABAA receptor positive allosteric modulator. Alphadolone has antinociceptive effects. Alphadolone causes general anaesthesia.

HY-101665

Pagoclone	Agonist	≥98.0%
Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders.

HY-19271

NS-2710	Agonist	99.21%
NS-2710 is a high-efficacy GABAAα3 agonist with a K_i of 9.2 nM. NS-2710 can be used for anxiety research.

HY-119404

Diproqualone	Agonist	99.9%
diproqualone is methaqualone analogous with sedative, anxiolytic, anti-inflammatory and analgesic properties.

HY-100291

SX-3228	Agonist
SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC₅₀ of 17 nM.

HY-100799

ZAPA sulfate	Agonist	99.25%
ZAPA sulfate is an agonist at low affinity GABA_A-receptors. ZAPA sulfate induces membrane hyperpolarization of the Ascaris muscle cell with an EC₅₀ of 10.3 μM.

HY-A0198

Adinazolam	Agonist	≥99.0%
Adinazolam (U 41123) is a triazolobenzodiazepine. Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. Adinazolam has dual anxiolytic and antidepressant activities.

HY-10061

Lesogaberan	Agonist
Lesogaberan (AZD-3355) is a potent and selective GABA_B receptor agonist with an EC₅₀ of 8.6 nM for human recombinant GABA_B receptors. The affinity (K_is) of Lesogaberan for rat GABA_B and GABA_A receptors, as measured by displacement of [³H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.

HY-100664

Zopiclone N-oxide	Agonist	≥98.0%
Zopiclone N-oxide (RP 29753) is a less active metabolite of Zopiclone. Zopiclone N-oxide is also an impurity of Eszopiclone and is formed by the oxidation of Eszopiclone.

HY-14953

Imepitoin	Agonist	99.87%
Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.

HY-123840

MRK-623	Agonist	98.73%
MRK-623 (Compound 14k) is an orally active, high-affinity GABA_A receptor agonist, with the K_i values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect.

HY-100140

Pipequaline	Agonist	99.93%
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.

HY-Y1176R

Isonipecotic acid (Standard)	Agonist
Isonipecotic acid is a GABAA receptor partial agonist.

HY-101639

CP-409092	Agonist
CP-409092 is a partial agonist of GABA_A receptor, with anti-anxiety activity.

HY-14735

Arbaclofen placarbil	Agonist
Arbaclofen placarbil is a novel transported proagent of the active R-isomer of baclofen. Baclofen is a racemic GABA_B receptor agonist

HY-17030S

Acamprosate-d₃ calcium	Agonist	99.9%
Acamprosate-d₃ (calcium) is the deuterium labeled Acamprosate calcium. Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems.

HY-B0007S

Baclofen-d₄	Agonist	99.98%
Baclofen-d₄ is the deuterium labeled Baclofen. Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.

HY-110233S

Acamprosate-d₆ calcium	Agonist
Acamprosate-d₆ (calcium) is the deuterium labeled Acamprosate calcium. Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems.

GABA Receptor Compound Library

Compound library containing various GABA receptor inhibitors and activators.

211compounds HY-L120

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GABA Receptor

GABA Receptor

GABA Receptor Related Products (765)

Antibodies (14)

Related Compound Screening Libraries (1)

GABA Receptor Related Products (765):